Mucus-PVPA (mucus Phospholipid Vesicle-based Permeation Assay): An artificial permeability tool for drug screening and formulation development

The Phospholipid Vesicle-based Drug Permeability Assay: 5. Development towards an Automated Procedure for High Throughput Permeability Screening

A simple mucus test for cancer screening.

Comparative and correlative studies of the pathology and pathogenesis of colon cancer in animal models and human disease have resulted in conceptualization of 'field effect" theory and identification of markers that are expressed early during carcinogenesis. This assimilated body of knowledge has resulted in development of a simple rectal mucus test for colon cancer screening. The marker galact...

Liposomes for (trans)dermal drug delivery: the skin-PVPA as a novel in vitro stratum corneum model in formulation development.

Penetration potential of vesicles destined for trans(dermal) administration remains to be of great interests both in respect to drug therapy and cosmetic treatment. This study investigated the applicability of the phospholipid vesicle-based permeation assay (PVPA) as a novel in vitro skin barrier model for screening purposes in preformulation studies. Various classes of liposomes containing hyd...

development and implementation of an optimized control strategy for induction machine in an electric vehicle

in the area of automotive engineering there is a tendency to more electrification of power train. in this work control of an induction machine for the application of electric vehicle is investigated. through the changing operating point of the machine, adapting the rotor magnetization current seems to be useful to increase the machines efficiency. in the literature there are many approaches wh...

Development and Rheological Profiling of Biosimilar Mucus

This article presents the development of a biosimilar mucus mixture for assessment of the effect of mucus on drug absorption. The biosimilar mucus was optimized to represent a rheological profile similar to that of porcine intestinal mucus. This was obtained with a mixture of mucin, polyacrylic acid, lipids and BSA. INTRODUCTION The viscoelastic mucus layers covering the epithelial surfaces are...